Opioid Substitution Therapy

Opioid intoxication Opioid withdrawal slow sleepy hypotensive bradycardic hypopnoeic constricted pupils constipation "on the nod" agitated dilated pupils tachycardia hypertension piloerection (goosebumps) "orange peel" skin nausea, vomiting diarrhea wet signs: clammy/sweaty, tears, runny nose yawning headache and body cramps Choice of withdrawal Methadone Buprenorphine  Pure μ opioid receptor agonist Partial μ opioid receptor agonist,  ↑ efficacy ↓ … Continue reading Opioid Substitution Therapy

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Naltrexone

Mechanism of Action Opioid antagonist reversible blockage of of opioid receptors (24-72 h), preventing opioid effects i.e. euphoria Alcohol dependence reduces cravings for alcohol and possibly reduces some of its pleasurable effects by blocking effects of endogenous opioids Adverse effects nausea, headache, dizziness, anxiety, fatigue, insomina and sleepiness Contraindications Physical dependence on opioids or acute … Continue reading Naltrexone