Mechanism of Action Opioid antagonist reversible blockage of of opioid receptors (24-72 h), preventing opioid effects i.e. euphoria Alcohol dependence reduces cravings for alcohol and possibly reduces some of its pleasurable effects by blocking effects of endogenous opioids Adverse effects nausea, headache, dizziness, anxiety, fatigue, insomina and sleepiness Contraindications Physical dependence on opioids or acute … Continue reading Naltrexone


Alcohol Withdrawal Delirium (Delirium Tremens)

Alcohol withdrawal delirium should be treated as a medical emergency as it has a mortality rate of up to 4%. If the patient does not respond to early treatment, management may need to occur in a highly monitored environment such as an intensive care or a high-dependency unit. Furthermore, the degree of sedation required for … Continue reading Alcohol Withdrawal Delirium (Delirium Tremens)